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Dokumenttyp:
journal article 
Autor(en):
Greif, PA; Eck, SH; Konstandin, NP; Benet-Pagès, A; Ksienzyk, B; Dufour, A; Vetter, AT; Popp, HD; Lorenz-Depiereux, B; Meitinger, T; Bohlander, SK; Strom, TM 
Titel:
Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing. 
Abstract:
Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next generation technology, was used as a systematic approach to identify mutations in genomes of various types of tumors including melanoma, lung and breast cancer, as well as acute myeloid leukemia (AML). Here, we identify tumor-specific somatic mutations by sequencing transcriptionally active genes. Mutations were detected by comparing the transcriptome sequence of an AML sample with the corresponding...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2011 
Band / Volume:
25 
Heft / Issue:
Seitenangaben Beitrag:
821-7 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
r Humangenetik