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Dokumenttyp:
journal article 
Autor(en):
Winkelmann, J; Czamara, D; Schormair, B; Knauf, F; Schulte, EC; Trenkwalder, C; Dauvilliers, Y; Polo, O; Högl, B; Berger, K; Fuhs, A; Gross, N; Stiasny-Kolster, K; Oertel, W; Bachmann, CG; Paulus, W; Xiong, L; Montplaisir, J; Rouleau, GA; Fietze, I; Vávrová, J; Kemlink, D; Sonka, K; Nevsimalova, S; Lin, SC; Wszolek, Z; Vilariño-Güell, C; Farrer, MJ; Gschliesser, V; Frauscher, B; Falkenstetter, T; Poewe, W; Allen, RP; Earley, CJ; Ondo, WG; Le, WD; Spieler, D; Kaffe, M; Zimprich, A; Kettunen, J; P...    »
 
Titel:
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 
Abstract:
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that occurs mainly in resting situations during the evening or at night. Moving the legs or walking leads to an improvement of symptoms. Concomitantly, patients report sleep disturbances with consequences such as reduced daytime functioning. We conduct...    »
 
Zeitschriftentitel:
PLoS Genet 
Jahr:
2011 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e1002171 
Sprache:
eng 
Print-ISSN:
1553-7390 
TUM Einrichtung:
Neurologische Klinik und Poliklinik; r Humangenetik