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Dokumenttyp:
journal article 
Autor(en):
Hauser, S; Bickel, L; Weinspach, D; Gerg, M; Schäfer, MK; Pfeifer, M; Hazin, J; Schelter, F; Weidle, UH; Ramser, J; Volkmann, J; Meindl, A; Schmitt, M; Schrötzlmair, F; Altevogt, P; Krüger, A 
Titel:
Full-length L1CAM and not its ?2?27 splice variant promotes metastasis through induction of gelatinase expression. 
Abstract:
Tumour-specific splicing is known to contribute to cancer progression. In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2 and 27 (SV-L1CAM). It has not been elucidated so far whether SV-L1CAM, classically considered as tumour-associated, or whether FL-L1CAM is the metastasis-promoting isoform. Here, we show that both var...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2011 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e18989 
Sprache:
eng 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung; Frauenklinik und Poliklinik