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Dokumenttyp:
journal article 
Autor(en):
Gilles, S; Fekete, A; Zhang, X; Beck, I; Blume, C; Ring, J; Schmidt-Weber, C; Behrendt, H; Schmitt-Kopplin, P; Traidl-Hoffmann, C 
Titel:
Pollen metabolome analysis reveals adenosine as a major regulator of dendritic cell-primed T(H) cell responses. 
Abstract:
Water-soluble components from pollen modulate dendritic cell (DC) functions, such as IL-12 secretion and 3'-5'-cyclic adenosine monophosphate (cAMP) signaling and migration, possibly contributing to the establishment of a T(H)2-dominated immune response against pollen. Because these effects could not solely be attributed to the previously identified pollen-associated lipid mediators, the pollen metabolome was analyzed for candidate immunomodulatory substances.We sought to perform an analysis of...    »
 
Zeitschriftentitel:
J Allergy Clin Immunol 
Jahr:
2011 
Band / Volume:
127 
Heft / Issue:
Seitenangaben Beitrag:
454-461.e1-9 
Sprache:
eng 
Print-ISSN:
0091-6749 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung; r Dermatologie und Allergologie