Kurzfassung:
In my study, I demonstrate that in Crybb2 mutant mice, O377, the hippocampus volume is reduced compared with wild type. In addition, the cell density of parvalbumin positive GABAergic interneuron is reduced in an age-dependent manner, specifically in ventral hippocampus. Furthermore, loss of dendritic complexity in hippocampal neurons and less astrogensis in adult O377 mutants are also observed. Up-regulation of Capn3 and Tmsb4x caused by increase of calcium concentration in hippocampal neurons is associated with these observed changes in O377 mutants. All results suggest that Crybb2 is a new candidate gene for psychiatric disorders, especially for schizophrenia.