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Dokumenttyp:
journal article 
Autor(en):
Willis, M; Kaufmann, WA; Wietzorrek, G; Hutter-Paier, B; Moosmang, S; Humpel, C; Hofmann, F; Windisch, M; Knaus, HG; Marksteiner, J 
Titel:
L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations. 
Abstract:
Cumulative evidence indicates that amyloid-beta peptides exert some of their neurodegenerative effects through modulation of L-type voltage gated calcium channels, which play key roles in a diverse range of CNS functions. In this study we examined the expression of CaV1.2 L-type voltage gated calcium channels in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations by immunohistochemistry in light and electron microscopy. In hippocampal layer...    »
 
Zeitschriftentitel:
J Alzheimers Dis 
Jahr:
2010 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
1167-80 
Sprache:
eng 
Print-ISSN:
1387-2877 
TUM Einrichtung:
r Pharmakologie und Toxikologie