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Dokumenttyp:
journal article 
Autor(en):
Langwieser, N; Christel, CJ; Kleppisch, T; Hofmann, F; Wotjak, CT; Moosmang, S 
Titel:
Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels. 
Abstract:
Ca(2+) influx through postsynaptic Ca(v)1.x L-type voltage-gated channels (LTCCs) is particularly effective in activating neuronal biochemical signaling pathways that might be involved in Hebbian synaptic plasticity (i.e., long-term potentiation and depression) and learning and memory. Here, we demonstrate that Ca(v)1.2 is the functionally relevant LTCC isoform in the thalamus-amygdala pathway of mice. We further show that acute pharmacological block of LTCCs abolishes Hebbian plasticity in the...    »
 
Zeitschriftentitel:
J Neurosci 
Jahr:
2010 
Band / Volume:
30 
Heft / Issue:
25 
Seitenangaben Beitrag:
8367-75 
Sprache:
eng 
Print-ISSN:
0270-6474 
TUM Einrichtung:
r Pharmakologie und Toxikologie