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Dokumenttyp:
journal article 
Autor(en):
Fletcher, O; Johnson, N; Silva, ID; Orr, N; Ashworth, A; Nevanlinna, H; Heikkinen, T; Aittomaki, K; Blomqvist, C; Burwinkel, B; Bartram, CR; Meindl, A; Schmutzler, RK; Cox, A; Brock, I; Elliott, G; Reed, MWR; Southey, MC; Smith, L; Spurdle, AB; Hopper, JL; Couch, FJ; Olson, JE; Wang, XS; Fredericksen, Z; Schurmann, P; Waltes, R; Bremer, M; Dork, T; Devilee, P; van Asperen, CJ; Tollenaar, RAEM; Seynaeve, C; Hall, P; Czene, K; Humphreys, K; Liu, JJ; Ahmed, S; Dunning, AM; Maranian, M; Pharoah, PDP...    »
 
Titel:
Missense Variants in ATM in 26,101 Breast Cancer Cases and 29,842 Controls 
Abstract:
Background: Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants remains contentious. Methods: We have genotyped five polymorphic (minor allele frequency, 0.9-2.6%) missense single nucleotide polymorphisms (SNP) in ATM (S49C, S707P, F858L, P1054R, and L1420F) in 26,101 breast cancer cases and 29,842 controls from 23 studies in the Breast Cancer Association Consortium. Results: Combining the data from all five SNPs, the odds ratio (...    »
 
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev 
Jahr:
2010 
Band / Volume:
19 
Heft / Issue:
Seitenangaben Beitrag:
2143-2151 
Sprache:
eng 
Print-ISSN:
1055-9965 
TUM Einrichtung:
Frauenklinik und Poliklinik