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Dokumenttyp:
journal article 
Autor(en):
Dahlhoff, M; Algül, H; Siveke, JT; Lesina, M; Wanke, R; Wartmann, T; Halangk, W; Schmid, RM; Wolf, E; Schneider, MR 
Titel:
Betacellulin protects from pancreatitis by activating stress-activated protein kinase. 
Abstract:
Acute pancreatitis (AP) is a serious, unpredictable clinical problem, the pathophysiology of which is poorly understood. Here, we evaluate whether betacellulin (BTC), a ligand of the epidermal growth factor receptor also able to activate the proapoptotic ERBB4 receptor, can protect against experimental AP.AP was induced in transgenic mice overexpressing BTC (BTC-tg), control mice, or control mice after administration of recombinant BTC. The severity of pancreatitis was assessed by measurements o...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2010 
Band / Volume:
138 
Heft / Issue:
Seitenangaben Beitrag:
1585-94, 1594.e1-3 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik