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Dokumenttyp:
journal article 
Autor(en):
Schüler, S; Fritsche, P; Diersch, S; Arlt, A; Schmid, RM; Saur, D; Schneider, G 
Titel:
HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (HDACs), especially the class I HDACs HDAC1, 2 and 3 are highly expressed in this disease, little is known about HDAC isoenzyme specific functions.Depletion of HDAC2, but not HDAC1, in the pancreatic cancer cell lines MiaPaCa2 and Panc1 resulted in a marked sensitization towards the tumor ne...    »
 
Zeitschriftentitel:
Mol Cancer 
Jahr:
2010 
Band / Volume:
Seitenangaben Beitrag:
80 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik