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Dokumenttyp:
journal article 
Autor(en):
Sarafoff, N; Sibbing, D; Sonntag, U; Ellert, J; Schulz, S; Byrne, RA; Mehilli, J; Schömig, A; Kastrati, A 
Titel:
Risk of drug-eluting stent thrombosis in patients receiving proton pump inhibitors. 
Abstract:
Clopidogrel is a prodrug that is converted via the hepatic cytochrome P450 system into its active thiol metabolite. Evidence is accumulating that proton pump inhibitors (PPIs) inhibit this enzymatic pathway and may therefore attenuate the antiplatelet effect of clopidogrel. The objective of this study was to investigate whether patients on clopidogrel therapy after drug-eluting stent (DES) placement who also receive a PPI are at higher risk of stent thrombosis (ST). This is a retrospective analy...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2010 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
626-32 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik