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Dokumenttyp:
journal article 
Autor(en):
Thiermann, H; Seeger, T; Gonder, S; Herkert, N; Antkowiak, B; Zilker, T; Eyer, F; Worek, F 
Titel:
Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds. 
Abstract:
Dysfunction of respiratory muscles is a life-threatening complication in poisoning by organophosphorus compounds (OPs). It is both of central and peripheral origin due to impaired cholinergic signalling upon inhibition of acetylcholinesterase (AChE). The dysfunction at neuromuscular synapses is not amenable to anticholinergics and remains a therapeutic challenge. Thus, a clear understanding of the distinct mechanisms occurring at neuromuscular synapses is decisive for the development and improve...    »
 
Zeitschriftentitel:
Chem Biol Interact 
Jahr:
2010 
Band / Volume:
187 
Heft / Issue:
1-3 
Seitenangaben Beitrag:
265-9 
Sprache:
eng 
Print-ISSN:
0009-2797 
TUM Einrichtung:
Toxikologische Abteilung