Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Chalmin, F; Ladoire, S; Mignot, G; Vincent, J; Bruchard, M; Remy-Martin, JP; Boireau, W; Rouleau, A; Simon, B; Lanneau, D; De Thonel, A; Multhoff, G; Hamman, A; Martin, F; Chauffert, B; Solary, E; Zitvogel, L; Garrido, C; Ryffel, B; Borg, C; Apetoh, L; Rébé, C; Ghiringhelli, F 
Titel:
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. 
Abstract:
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and MDSCs determines the suppressive activity of the MDSCs via activation of Stat3. In ad...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2010 
Band / Volume:
120 
Heft / Issue:
Seitenangaben Beitrag:
457-71 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
r Strahlentherapie und Radiologische Onkologie