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Dokumenttyp:
journal article 
Autor(en):
Friedrich, L; Stangl, S; Hahne, H; Küster, B; Köhler, P; Multhoff, G; Skerra, A 
Titel:
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics. 
Abstract:
Hsp70, the major stress-inducible member of the 70 kDa heat shock protein family, is frequently exposed on the plasma membrane of human tumours and, even more pronounced, on metastases but not detectable on normal tissues. The mouse monoclonal antibody cmHsp70.1, which recognizes a peptide epitope in the C-terminal substrate binding domain of both human and murine Hsp70, provides a promising reagent for the monitoring of Hsp70-positive tumours during cancer therapy. Here, we describe the variabl...    »
 
Zeitschriftentitel:
Protein Eng Des Sel 
Jahr:
2010 
Band / Volume:
23 
Heft / Issue:
Seitenangaben Beitrag:
161-8 
Sprache:
eng 
Print-ISSN:
1741-0126 
TUM Einrichtung:
r Strahlentherapie und Radiologische Onkologie