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Document type:
journal article 
Author(s):
Lohmeyer, JA; Liu, F; Krüger, S; Lindenmaier, W; Siemers, F; Machens, HG 
Title:
Use of gene-modified keratinocytes and fibroblasts to enhance regeneration in a full skin defect. 
Abstract:
With the development of cell-based gene transfer techniques, genetically modified human keratinocytes (Kc) and fibroblasts (Fb) have been proven to be a better choice in wound repair.This study was designed to construct in one step a gene-modified artificial skin by a genetically engineered Kc expressing PDGF-BB and Fb expressing VEGF(165) and bFGF. The wound healing effect in a full-thickness wound model was then observed. Unmodified artificial skin served as control. On the post-operative days...    »
 
Journal title abbreviation:
Langenbecks Arch Surg 
Year:
2011 
Journal volume:
396 
Journal issue:
Pages contribution:
543-50 
Language:
eng 
Print-ISSN:
1435-2443 
TUM Institution:
Klinik und Poliklinik für Plastische Chirurgie und Handchirurgie