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Document type:
journal article 
Author(s):
Langer, R; Becker, K; Feith, M; Friess, H; Höfler, H; Keller, G 
Title:
Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases. 
Abstract:
We present a series of 10 primary esophageal melanomas of Caucasian patients characterized clinicopathologically and on the molecular level. Mutation analysis for c-Kit (exons 9, 11, 13 and 17), PDGFR (exons 12, 14 and 18), NRAS and KRAS were determined using PCR and direct sequencing. Analysis of the V600E mutation of BRAF was performed using mutation-specific PCR. Expression of c-Kit and PDGFR-A was additionally determined using immunohistochemistry. One tumor harbored a missense mutation in t...    »
 
Journal title abbreviation:
Mod Pathol 
Year:
2011 
Journal volume:
24 
Journal issue:
Pages contribution:
495-501 
Language:
eng 
Print-ISSN:
0893-3952 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Chirurgiesche Klinik und Poliklinik