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Document type:
journal article 
Author(s):
Gonzalez-Vasconcellos, I; Domke, T; Kuosaite, V; Esposito, I; Sanli-Bonazzi, B; Nathrath, M; Atkinson, MJ; Rosemann, M 
Title:
Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice. 
Abstract:
Osteosarcoma is the most frequent secondary malignancy following radiotherapy of patients with bilateral retinoblastoma. This suggests that the Rb1 tumour suppressor gene might confer genetic susceptibility towards radiation-induced osteosarcoma. To define the contribution of the Rb1 pathway in the multistep process of radiation carcinogenesis, we evaluated somatic allelic changes affecting the Rb1 gene itself as well as its upstream regulator p16 in murine osteosarcoma induced by (227)Th incorp...    »
 
Journal title abbreviation:
Radiat Environ Biophys 
Year:
2011 
Journal volume:
50 
Journal issue:
Pages contribution:
135-41 
Language:
eng 
Print-ISSN:
0301-634X 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Kinderklinik und Poliklinik