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Document type:
journal article 
Author(s):
Geelhaar, A; Moos, V; Schinnerling, K; Allers, K; Loddenkemper, C; Fenollar, F; Lascola, B; Raoult, D; Schneider, T 
Title:
Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease. 
Abstract:
Whipple's disease is a chronic multisystemic infection caused by Tropheryma whipplei that is characterized by arthritis, weight loss, and diarrhea. The immunological defects in the duodenal mucosa, the site of major replication of the agent underlying the pathogenesis of Whipple's disease, are poorly understood. Mucosal immunoglobulins are essential for the defense against intestinal pathogens; therefore, we analyzed the B-cell response in duodenal specimens and sera of Whipple's disease patien...    »
 
Journal title abbreviation:
Infect Immun 
Year:
2010 
Journal volume:
78 
Journal issue:
11 
Pages contribution:
4589-92 
Language:
eng 
Print-ISSN:
0019-9567 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie