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Document type:
journal article 
Author(s):
Reece, ST; Loddenkemper, C; Askew, DJ; Zedler, U; Schommer-Leitner, S; Stein, M; Mir, FA; Dorhoi, A; Mollenkopf, HJ; Silverman, GA; Kaufmann, SH 
Title:
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. 
Abstract:
The hallmark of human Mycobacterium tuberculosis infection is the presence of lung granulomas. Lung granulomas can have different phenotypes, with caseous necrosis and hypoxia present within these structures during active tuberculosis. Production of NO by the inducible host enzyme NOS2 is a key antimycobacterial defense mechanism that requires oxygen as a substrate; it is therefore likely to perform inefficiently in hypoxic regions of granulomas in which M. tuberculosis persists. Here we have u...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2010 
Journal volume:
120 
Journal issue:
Pages contribution:
3365-76 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie