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Dokumenttyp:
journal article 
Autor(en):
Molatore, S; Kiermaier, E; Jung, CB; Lee, M; Pulz, E; Hofler, H; Atkinson, MJ; Pellegata, NS 
Titel:
Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors. 
Abstract:
BACKGROUND: p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor. The finding that a spontaneous germline frameshift mutation in Cdkn1b (encoding p27) causes the MENX multiple endocrine neoplasia syndrome in the rat provided the first evidence that Cdkn1b is a tumor susceptibility gene for endocrine tumors. Noteworthy, germline p27 mutations were also identified in human patients presenting with endocrine tumors. At present, it is not clear which fea...    »
 
Zeitschriftentitel:
Mol Cancer 
Jahr:
2010 
Band / Volume:
Seitenangaben Beitrag:
116 
Sprache:
eng 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie