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Dokumenttyp:
journal article 
Autor(en):
Allers, K; Loddenkemper, C; Hofmann, J; Unbehaun, A; Kunkel, D; Moos, V; Kaup, FJ; Stahl-Hennig, C; Sauermann, U; Epple, HJ; Schneider, T 
Titel:
Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesus macaques. 
Abstract:
The gastrointestinal tract represents a major site for human and simian immunodeficiency virus (HIV and SIV) replication and CD4(+) T-cell depletion. Despite severe depletion of mucosal CD4(+) T cells, FOXP3(+) regulatory CD4(+) T cells (T(reg)) are highly increased in the gut mucosa of chronically HIV-infected individuals and may contribute to HIV pathogenesis, either by their immunosuppressive function or as a significant target cell population for virus production. Little is known about the s...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2010 
Band / Volume:
84 
Heft / Issue:
Seitenangaben Beitrag:
3259-69 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie