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Dokumenttyp:
journal article 
Autor(en):
Yousefi, BH; Manook, A; Drzezga, A; von Reutern, B; Schwaiger, M; Wester, HJ; Henriksen, G 
Titel:
Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging ?-amyloid plaques in Alzheimer's disease. 
Abstract:
We report a novel series of (11)C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as tracers for imaging of cerebral ?-amyloid (A?) deposits in patients with Alzheimer's disease (AD) by means of positron emission tomography (PET). From a series of 11 compounds, candidates were identified to have a high binding affinity for A?. Selected compounds were prepared as O- or N-[(11)C]methyl derivatives and shown to have a high initial brain uptake in wild-type mice (range 1.9-9.2% I.D./g at 5 min). 2-(p-[(...    »
 
Zeitschriftentitel:
J Med Chem 
Jahr:
2011 
Band / Volume:
54 
Heft / Issue:
Seitenangaben Beitrag:
949-56 
Sprache:
eng 
Print-ISSN:
0022-2623 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik