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Dokumenttyp:
journal article 
Autor(en):
Liu, S; Liu, Z; Chen, K; Yan, Y; Watzlowik, P; Wester, HJ; Chin, FT; Chen, X 
Titel:
18F-labeled galacto and PEGylated RGD dimers for PET imaging of ?v?3 integrin expression. 
Abstract:
In vivo imaging of ?(v)?(3) has important diagnostic and therapeutic applications. (18)F-Galacto-arginine-glycine-aspartic acid (RGD) has been developed for positron emission tomography (PET) imaging of integrin ?(v)?(3) expression and is now being tested on humans. Dimerization and multimerization of cyclic RGD peptides have been reported to improve the integrin ?(v)?(3)-binding affinity due to the polyvalency effect. Here, we compared a number of new dimeric RGD peptide tracers with the clinic...    »
 
Zeitschriftentitel:
Mol Imaging Biol 
Jahr:
2010 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
530-8 
Sprache:
eng 
Print-ISSN:
1536-1632 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik