User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Kimura, T; Ishikawa, K; Sakasegawa, Y; Teruya, K; Sata, T; Schätzl, H; Doh-ura, K 
Title:
GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. 
Abstract:
Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly decreased the abnormal prion protein level but paradoxically increased the normal prion protein level. Treatment with a gabrb1-specific inhibitor, salicylidene salicylhydrazide, dose-depe...    »
 
Journal title abbreviation:
FEBS Lett 
Year:
2010 
Journal volume:
584 
Journal issue:
Pages contribution:
1193-8 
Language:
eng 
Print-ISSN:
0014-5793 
TUM Institution:
Institut für Virologie