Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Grimm, M; Kim, M; Rosenwald, A; von Rahden, B; Tsaur, I; Meier, E; Heemann, U; Germer, CT; Gasser, M; Waaga-Gasser, AM 
Titel:
Tumour-mediated TRAIL-Receptor expression indicates effective apoptotic depletion of infiltrating CD8+ immune cells in clinical colorectal cancer. 
Abstract:
Expression of apoptosis-related proteins on tumour cells has been shown in several experimental models to be an efficient mechanism for a counterattack against host anti-tumour immune responses in solid tumours. Here we provide a clinical evidence for such a tumour immune escape mechanism by demonstrating tumour to T cell-directed death receptor signalling (TRAIL/TRAIL-Receptor (TRAIL-R)) in colorectal cancer (CRC). In a series of patients with CRC and completed 5-year follow up, we investigated...    »
 
Zeitschriftentitel:
Eur J Cancer 
Jahr:
2010 
Band / Volume:
46 
Heft / Issue:
12 
Seitenangaben Beitrag:
2314-23 
Sprache:
eng 
Print-ISSN:
0959-8049 
TUM Einrichtung:
r Nephrologie