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Dokumenttyp:
journal article 
Autor(en):
Brzostek, J; Chai, JG; Gebhardt, F; Busch, DH; Zhao, R; van der Merwe, PA; Gould, KG 
Titel:
Ligand dimensions are important in controlling NK-cell responses. 
Abstract:
Size-dependent protein segregation at the cell-cell contact interface has been suggested to be critical for regulation of lymphocyte function. We investigated the role of ligand dimensions in regulation of mouse NK-cell activation and inhibition. Elongated forms of H60a, a mouse NKG2D ligand, were generated and expressed stably in the RMA cell line. RMA cells expressing the normal size H60a were lysed efficiently by both freshly isolated and IL-2 stimulated C57BL/6 mouse-derived NK cells; howev...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2010 
Band / Volume:
40 
Heft / Issue:
Seitenangaben Beitrag:
2050-9 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene