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Document type:
journal article 
Author(s):
Rzymski, T; Milani, M; Pike, L; Buffa, F; Mellor, HR; Winchester, L; Pires, I; Hammond, E; Ragoussis, I; Harris, AL 
Title:
Regulation of autophagy by ATF4 in response to severe hypoxia. 
Abstract:
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small interfering RNA (siRNA) and microarray analysis to provide the first whole-genome analysis of genes regulated by ATF4 in cancer cells in response to severe and prolonged hypoxic stress....    »
 
Journal title abbreviation:
Oncogene 
Year:
2010 
Journal volume:
29 
Journal issue:
31 
Pages contribution:
4424-35 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler