Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
den Hollander, J; Rimpi, S; Doherty, JR; Rudelius, M; Buck, A; Hoellein, A; Kremer, M; Graf, N; Scheerer, M; Hall, MA; Goga, A; von Bubnoff, N; Duyster, J; Peschel, C; Cleveland, JL; Nilsson, JA; Keller, U 
Titel:
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. 
Abstract:
Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators. Here, we report that c-Myc regulates the expression of Aurora A and B kinases (Aurka and Aurkb), and that Aurka and Aurkb transcripts and protein levels are highly elevated in Myc-driven B-cell lymphomas in both mice and humans. The induction of Aurka by Myc is transcriptional and is directly mediated via E-boxes, whereas Aurkb is regulated indirectly. Blocking Aurka/b kinase a...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2010 
Band / Volume:
116 
Heft / Issue:
Seitenangaben Beitrag:
1498-505 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie; Nuklearmedizinische Klinik und Poliklinik