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Document type:
journal article 
Author(s):
Anz, D; Koelzer, VH; Moder, S; Thaler, R; Schwerd, T; Lahl, K; Sparwasser, T; Besch, R; Poeck, H; Hornung, V; Hartmann, G; Rothenfusser, S; Bourquin, C; Endres, S 
Title:
Immunostimulatory RNA blocks suppression by regulatory T cells. 
Abstract:
The role of immune suppression by regulatory T (Treg) cells in the maintenance of immune homeostasis is well established. However, little is known about how Treg cell function is inhibited on viral infection to allow the development of a protective immune response. As viral RNA is a crucial mediator for activation of antiviral immunity, we examined the effects of immunostimulatory RNA and infection with RNA viruses on Treg cell function. We show that synthetic RNA oligonucleotides potently inhib...    »
 
Journal title abbreviation:
J Immunol 
Year:
2010 
Journal volume:
184 
Journal issue:
Pages contribution:
939-46 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
III. Medizinische Klinik und Poliklinik