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Dokumenttyp:
journal article 
Autor(en):
Neely, GG; Kuba, K; Cammarato, A; Isobe, K; Amann, S; Zhang, L; Murata, M; Elmén, L; Gupta, V; Arora, S; Sarangi, R; Dan, D; Fujisawa, S; Usami, T; Xia, CP; Keene, AC; Alayari, NN; Yamakawa, H; Elling, U; Berger, C; Novatchkova, M; Koglgruber, R; Fukuda, K; Nishina, H; Isobe, M; Pospisilik, JA; Imai, Y; Pfeufer, A; Hicks, AA; Pramstaller, PP; Subramaniam, S; Kimura, A; Ocorr, K; Bodmer, R; Penninger, JM 
Titel:
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. 
Abstract:
Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved genes under conditions of stress. We present a first global roadmap of pathways potentially playing conserved roles in the cardiovascular system. One critical pathway identified was the CCR4-Not complex implicated in transcriptional and posttranscriptional regulatory mechanisms. Silencing of CCR4-Not components in adult Dro...    »
 
Zeitschriftentitel:
Cell 
Jahr:
2010 
Band / Volume:
141 
Heft / Issue:
Seitenangaben Beitrag:
142-53 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
r Humangenetik