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Document type:
journal article 
Author(s):
Holzmüller, R; Mantwill, K; Haczek, C; Rognoni, E; Anton, M; Kasajima, A; Weichert, W; Treue, D; Lage, H; Schuster, T; Schlegel, J; Gänsbacher, B; Holm, PS 
Title:
YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma. 
Abstract:
The human Y-box binding protein 1 (YB-1) is known to be a promising target for cancer therapy. We have demonstrated that YB-1 plays an important role in the adenoviral life cycle by regulating the adenoviral E2-gene expression. Thus, we studied the oncolytic effect of the recombinant adenovirus Ad-Delo3-RGD, in which the transactivation domain CR3 of the E1A protein is ablated to enable viral replication only in YB-1 positive cancer cells. In vitro Southern Blot analysis and cytopathic effect as...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2010 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Institut für Medizinische Statistik und Epidemiologie ; Institut für Allgemeine Pathologie und pathologische Anatomie