Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Meda, C; Plank, C; Mykhaylyk, O; Schmidt, K; Mayer, B 
Titel:
Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. 
Abstract:
Human umbilical vein endothelial cells (HUVECs) were established as in vitro models for the modulation of endothelial function and cell viability by statins. Emphasis was placed on the biphasic effects of the drugs on nitric oxide (NO) bioavailability and cytotoxicity, as well as drug interference with the interaction of endothelial NO synthase (eNOS) with caveolin-1 (Cav-1). Incubation of HUVECs with fluvastatin, lovastatin or cerivastatin for 24 h caused an approximately 3-fold upregulation of...    »
 
Zeitschriftentitel:
Pharmacol Rep 
Jahr:
2010 
Band / Volume:
62 
Heft / Issue:
Seitenangaben Beitrag:
100-12 
Sprache:
eng 
Print-ISSN:
1734-1140 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung