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Document type:
journal article 
Author(s):
Chen, W; Tsai, SJ; Sheu, HM; Tsai, JC; Zouboulis, CC 
Title:
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. 
Abstract:
Human sebaceous gland possesses all the steroidogenic enzymes required for androgen synthesis. It remains unclear whether the testosterone produced in situ mainly derives from circulating dehydroepiandrosterone (DHEA) or from de novo synthesis utilizing serum cholesterol. Using testosterone radioimmunoassay, we found that testosterone was barely detectable in the supernatant of cultured human SZ95 sebocytes when cholesterol was added alone, indicating a low basal expression of steroidogenic acut...    »
 
Journal title abbreviation:
Exp Dermatol 
Year:
2010 
Journal volume:
19 
Journal issue:
Pages contribution:
470-2 
Language:
eng 
Print-ISSN:
0906-6705 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie