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Document type:
journal article 
Author(s):
Ellinghaus, E; Ellinghaus, D; Stuart, PE; Nair, RP; Debrus, S; Raelson, JV; Belouchi, M; Fournier, H; Reinhard, C; Ding, J; Li, Y; Tejasvi, T; Gudjonsson, J; Stoll, SW; Voorhees, JJ; Lambert, S; Weidinger, S; Eberlein, B; Kunz, M; Rahman, P; Gladman, DD; Gieger, C; Wichmann, HE; Karlsen, TH; Mayr, G; Albrecht, M; Kabelitz, D; Mrowietz, U; Abecasis, GR; Elder, JT; Schreiber, S; Weichenthal, M; Franke, A 
Title:
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. 
Abstract:
Psoriasis is a multifactorial skin disease characterized by epidermal hyperproliferation and chronic inflammation, the most common form of which is psoriasis vulgaris (PsV). We present a genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany, with follow-up of the 147 most significant SNPs in 2,746 PsV cases and 4,140 controls from three independent replication panels. We identified an association at TRAF3IP2 on 6q21 and genotyped two SNPs at this loc...    »
 
Journal title abbreviation:
Nat Genet 
Year:
2010 
Journal volume:
42 
Journal issue:
11 
Pages contribution:
991-5 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie