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Dokumenttyp:
journal article 
Autor(en):
Hammer, M; Echtenachter, B; Weighardt, H; Jozefowski, K; Rose-John, S; Männel, DN; Holzmann, B; Lang, R 
Titel:
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. 
Abstract:
The mitogen-activated protein kinase phosphatase Dusp1 (also known as MKP-1) is essential for control of the inflammatory response to systemic challenge with the lipopolysaccharide of Gram-negative bacteria. Here, we have investigated the consequences of Dusp1-deficiency in colon ascendens stent peritonitis (CASP) and caecal ligation and puncture (CLP), two mouse models of septic peritonitis. Following CASP, Dusp1(-/-) mice had increased serum levels of CCL4, interleukin-10 (IL-10) and IL-6, wit...    »
 
Zeitschriftentitel:
Immunology 
Jahr:
2010 
Band / Volume:
131 
Heft / Issue:
Seitenangaben Beitrag:
395-404 
Sprache:
eng 
Print-ISSN:
0019-2805 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik