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Dokumenttyp:
journal article 
Autor(en):
Kong, B; Michalski, CW; Hong, X; Valkovskaya, N; Rieder, S; Abiatari, I; Streit, S; Erkan, M; Esposito, I; Friess, H; Kleeff, J 
Titel:
AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-?-mediated ERK signaling. 
Abstract:
Epithelial-to-mesenchymal transdifferentiation (EMT) mediated by transforming growth factor-? (TGF-?) signaling leads to aggressive cancer progression. In this study, we identified zinc-?2-glycoprotein (AZGP1, ZAG) as a tumor suppressor in pancreatic ductal adenocarcinoma whose expression is lost due to histone deacetylation. In vitro, ZAG silencing strikingly increased invasiveness of pancreatic cancer cells accompanied by the induction of a mesenchymal phenotype. Expression analysis of a set o...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2010 
Band / Volume:
29 
Heft / Issue:
37 
Seitenangaben Beitrag:
5146-58 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik