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Dokumenttyp:
journal article 
Autor(en):
Mutze, K; Langer, R; Becker, K; Ott, K; Novotny, A; Luber, B; Hapfelmeier, A; Göttlicher, M; Höfler, H; Keller, G 
Titel:
Histone Deacetylase (HDAC) 1 and 2 Expression and Chemotherapy in Gastric Cancer. 
Abstract:
BACKGROUND: Histone deacetylases (HDACs) modulate chromatin and may influence the effect of DNA-damaging drugs. We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options. METHODS: HDAC1/2 expression was analyzed immunohistochemically in 127 pretherapeutic biopsy samples of neoadjuvant (platinum/5-fluorouracil) chemotherapy-treated G...    »
 
Zeitschriftentitel:
Ann Surg Oncol 
Jahr:
2010 
Band / Volume:
17 
Heft / Issue:
12 
Seitenangaben Beitrag:
3336-43 
Sprache:
eng 
Print-ISSN:
1068-9265 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; Chirurgiesche Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie; r Toxikologie und Umwelthygiene