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Document type:
Zeitschriftenaufsatz 
Author(s):
Nishino T, Wedel T, Schmitt O, Schoenfelder M, Hirtreiter C, Schulz T, Kuhnel W, Michna H 
Title:
The xenoestrogen bisphenol A in the Hershberger assay: Androgen receptor regulation and morphometrical reactions indicate no major effects 
Abstract:
We evaluated androgen-like effects of bisphenol A (BPA) using orchiectomized Wistar rats. Animals were treated p.o. either with vehicle or with 3, 50, 200, 500 mg/kg bw/day BPA (n = 13) for 7 days. One group was treated s.c. with 1 mg/kg bw/day testosterone propionate (TP). Flutamide (FL) (3 mg/kg bw/day, p.o.) was used to antagonize androgen effects of the suprapharmacological dose (500 mg/kg bw/day) of BPA. Androgen-like effects of BPA on prostates and seminal vesicles were assessed by the Her...    »
 
Keywords:
Bisphenol A Prostate Seminal vesicle Immunohistochemistry Morphometry Densitometry Androgen receptor regulation PCNA MIB-5 Proliferation markers 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit 
Journal title:
Journal of Steroid Biochemistry and Molecular Biology 
Year:
2006 
Journal volume:
98 
Year / month:
2006-02 
Journal issue:
(2-3) 
Pages contribution:
155-163 
Reviewed:
ja 
Language:
en 
Print-ISSN:
0960-0760 
Semester:
WS 05-06 
TUM Institution:
Sportbiologie 
Occurrences: