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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Etgen, T; Sander, D; Chonchol, M; Briesenick, C; Poppert, H; Förstl, H; Bickel, H
- Titel:
- Chronic kidney disease is associated with incident cognitive impairment in the elderly: the INVADE study.
- Abstract:
- BACKGROUND: Limited data exist regarding the relationship between decreased renal function and cognitive impairment. METHODS: A total of 3679 participants of the Intervention Project on Cerebrovascular Diseases and Dementia in the Community of Ebersberg (INVADE) composed the community-based cohort study. Measures of renal function were estimated using the Cockcroft-Gault equation and divided into normal, mild and moderate-to-severe impaired renal function (creatinine clearance >or=60, 45-59 and <45 mL/min/1.73 m(2), respectively). The main outcome measures were cognitive impairment at baseline and new cognitive impairment after a 2-year follow-up. Cognitive function was measured using the 6-Item Cognitive Impairment Test (6CIT). Multiple logistic regression analysis was used to assess the association between renal function and cognitive impairment. RESULTS: At baseline, 396 participants (10.8%) had cognitive impairment. After the 2-year follow-up, 194 participants (6.2%) developed new cognitive impairment. The incidence of cognitive impairment across the groups with normal renal function, mild and moderate-to-severe kidney disease at baseline were 5.8, 9.9 and 21.5%, respectively. Multiple logistic regression analysis after adjustment for possible confounders including traditional cardiovascular risk factors showed a significant association for participants with moderate-to-severe kidney disease at baseline to develop new cognitive impairment after the 2-year follow-up [odds ratio: 2.14 (95% confidence interval: 1.18-3.87), P = 0.01]. CONCLUSIONS: In summary, moderate-to-severe impaired renal function is associated with incident cognitive impairment after 2 years in a large cohort of elderly subjects.
- Zeitschriftentitel:
- Nephrol Dial Transplant
- Jahr:
- 2009
- Band / Volume:
- 24
- Heft / Issue:
- 10
- Seitenangaben Beitrag:
- 3144-50
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1093/ndt/gfp230
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/19461010
- Print-ISSN:
- 0931-0509
- TUM Einrichtung:
- Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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