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Document type:
Zeitschriftenaufsatz 
Author(s):
Marczynski, Matthias; Rickert, Carolin A.; Semerdzhiev, Slav A.; van Dijk, Wouter R.; Segers-Nolten, Ine M. J.; Claessens, Mireille M. A. E.; Lieleg, Oliver 
Title:
α-Synuclein Penetrates Mucin Hydrogels Despite Its Mucoadhesive Properties 
Abstract:
Recent research indicates that the progression of Parkinson’s disease can start from neurons of the enteric nervous system, which are in close contact with the gastrointestinal epithelium: α-synuclein molecules can be transferred from these epithelial cells in a prion-like fashion to enteric neurons. Thin mucus layers constitute a defense line against the exposure of noninfected cells to potentially harmful α-synuclein species. We show that—despite its mucoadhesive properties—α-synuclein can tra...    »
 
Keywords:
Peptides and proteins, Monomers, Fluorescenc Molecules, Hydrogels 
Dewey Decimal Classification:
500 Naturwissenschaften 
Journal title:
Biomacromolecules 
Year:
2019 
Journal volume:
20 
Journal issue:
12 
Pages contribution:
4332-4344 
Covered by:
Scopus 
Reviewed:
ja 
Language:
en 
Publisher:
American Chemical Society (ACS) 
E-ISSN:
1525-77971526-4602 
Date of publication:
13.11.2019 
Semester:
WS 19-20 
TUM Institution:
Fachgebiet für Biomechanik, MW