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Document type:
Zeitschriftenaufsatz 
Author(s):
Yan, Hongji; Seignez, Cédric; Hjorth, Morgan; Winkeljann, Benjamin; Blakeley, Matthew; Lieleg, Oliver; Phillipson, Mia; Crouzier, Thomas 
Title:
Immune‐Informed Mucin Hydrogels Evade Fibrotic Foreign Body Response In Vivo 
Abstract:
The immune‐mediated foreign body response to biomaterial implants can trigger the formation of insulating fibrotic capsules that can compromise implant function. To address this challenge, the intrinsic bioactivity of the mucin biopolymer, a heavily glycosylated protein that forms the protective mucus gel covering mucosal epithelia, is leveraged. By using a bioorthogonal inverse electron demand Diels–Alder reaction, mucins are crosslinked into implantable hydrogels. It is shown that mucin hydrog...    »
 
Keywords:
B cells bovine submaxillary mucin fibrosis foreign body response hydrogels macrophages TGF‐β1 
Journal title:
Advanced Functional Materials 
Year:
2019 
Year / month:
2019-09 
Pages contribution:
1902581 
Covered by:
Web of Science 
Language:
en 
Fulltext / DOI:
Publisher:
Wiley 
E-ISSN:
1616-301X1616-3028 
Date of publication:
12.09.2019 
TUM Institution:
Fachgebiet für Biomechanik