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Document type:
journal article 
Author(s):
Khamis, Ramzi Y; Woollard, Kevin J; Hyde, Gareth D; Boyle, Joseph J; Bicknell, Colin; Chang, Shang-Hung; Malik, Talat H; Hara, Tetsuya; Mauskapf, Adam; Granger, David W; Johnson, Jason L; Ntziachristos, Vasilis; Matthews, Paul M; Jaffer, Farouc A; Haskard, Dorian O 
Title:
Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis. 
Abstract:
We aimed to develop a quantitative antibody-based near infrared fluorescence (NIRF) approach for the imaging of oxidized LDL in atherosclerosis. LO1, a well- characterized monoclonal autoantibody that reacts with malondialdehyde-conjugated LDL, was labeled with a NIRF dye to yield LO1-750. LO1-750 specifically identified necrotic core in ex vivo human coronary lesions. Injection of LO1-750 into high fat (HF) fed atherosclerotic Ldlr(-/-) mice led to specific focal localization within the aortic...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2016 
Journal volume:
Pages contribution:
21785 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Lehrstuhl für Biologische Bildgebung