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Document type:
journal article 
Author(s):
Lozano, Neus; Al-Ahmady, Zahraa S; Beziere, Nicolas S; Ntziachristos, Vasilis; Kostarelos, Kostas 
Title:
Monoclonal antibody-targeted PEGylated liposome-ICG encapsulating doxorubicin as a potential theranostic agent. 
Abstract:
Indocyanine green (ICG) is an FDA-approved, strongly photo-absorbent/fluorescent probe that has been incorporated into a clinically-relevant PEGylated liposome as a flexible optoacoustic contrast agent platform. This study describes the engineering of targeted PEGylated liposome-ICG using the anti-MUC-1 "humanized" monoclonal antibody (MoAb) hCTM01 as a tumour-specific theranostic system. We aimed to visualise non-invasively the tumour accumulation of these MoAb-targeted liposomes over time in t...    »
 
Journal title abbreviation:
Int J Pharm 
Year:
2015 
Journal volume:
482 
Journal issue:
1-2 
Pages contribution:
2-10 
Language:
eng 
Print-ISSN:
0378-5173 
TUM Institution:
Lehrstuhl für Biologische Bildgebung