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Document type:
journal article 
Author(s):
Maltsev, Oleg V; Marelli, Udaya Kiran; Kapp, Tobias G; Di Leva, Francesco Saverio; Di Maro, Salvatore; Nieberler, Markus; Reuning, Ute; Schwaiger, Markus; Novellino, Ettore; Marinelli, Luciana; Kessler, Horst 
Title:
Stable Peptides Instead of Stapled Peptides: Highly Potent ?v?6-Selective Integrin Ligands. 
Abstract:
The ?v?6 integrin binds the RGD-containing peptide of the foot and mouth disease virus with high selectivity. In this study, the long binding helix of this ligand was downsized to an enzymatically stable cyclic peptide endowed with sub-nanomolar binding affinity toward the ?v?6 receptor and remarkable selectivity against other integrins. Computational studies were performed to disclose the molecular bases underlying the high binding affinity and receptor subtype selectivity of this peptide. Fina...    »
 
Journal title abbreviation:
Angew Chem Int Ed Engl 
Year:
2016 
Journal volume:
55 
Journal issue:
Pages contribution:
1535-9 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0570-0833 
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Nuklearmedizinische Klinik und Poliklinik