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Document type:
Zeitschriftenaufsatz 
Author(s):
Schömig, Veronika J.; Käsdorf, Benjamin T.; Scholz, Christoph; Bidmon, Konstantinia; Lieleg, Oliver; Berensmeier, Sonja 
Title:
An optimized purification process for porcine gastric mucin with preservation of its native functional properties 
Abstract:
Purified gastric mucins are currently used for a wide range of applications e.g. as a model system for native mucus, as lubricants or antiviral/antibacterial supplements. However, commercially available porcine gastric mucins (PGM) do not exhibit gel-forming properties and show only greatly reduced anti-viral/anti-bacterial activity. Thus, we established a robust purification process for PGM, maintaining its desired properties such as lubricity, gel formation and the selective binding of molecul...    »
 
Keywords:
SOL-GEL TRANSITION; MUCUS GLYCOPROTEINS; CONCENTRATION POLARIZATION; HYDROPHOBIC SURFACES; STRUCTURAL-ANALYSIS; POLYMERIC STRUCTURE; PURIFY MUCINS; PH; ADSORPTION; FLUX 
Dewey Decimal Classification:
500 Naturwissenschaften 
Journal title:
RSC Adv. 
Year:
2016 
Year / month:
2016-04 
Journal issue:
50 
Pages contribution:
44932-44943 
Reviewed:
ja 
Language:
en 
Fulltext / DOI:
Publisher:
Royal Society of Chemistry (RSC) 
Date of publication:
01.01.2016