Login
- Original title:
- Synthesis of gamma-lactones for activity based protein profiling: Investigation of their protein reactivity and inhibition of bacterial virulence
- Translated title:
- Synthese von gamma-Lactonen zum aktivitätsbasierten Protein Profiling: Untersuchung ihrer Proteinreaktivität und Inhibition der bakteriellen Virulenz
- Author:
- Kunzmann, Martin Herbert
- Year:
- 2014
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Sieber, Stephan A. (Prof. Dr.)
- Referee:
- Sieber, Stephan A. (Prof. Dr.); Schneider, Sabine (Dr.)
- Language:
- en
- Subject group:
- CHE Chemie
- TUM classification:
- CHE 670d; CHE 827d; CHE 880d
- Abstract:
- Gamma-Butyrolactones were investigated for their protein reactivity and inhibition of bacterial virulence. This was achieved by synthesis of gamma-lactone probes for activity based protein profiling (ABPP), investigation of their protein reactivity using ABPP, the identification of bound proteins and the elucidation of the molecular mechanism of virulence inhibition. Two gamma-lactone probes showed a potent reduction of hemolysis and intracellular replication of Staphylococcus aureus by inhibiti... »
- Translated abstract:
- Gamma-Butyrolactone wurden auf ihre Proteinreaktivität und Inhibition der bakteriellen Virulenz untersucht. Dies gliedert sich in die Synthese der Lactone für aktivitätsbasierendes Protein Profiling (ABPP), der Untersuchung ihrer Proteinreaktivität durch ABPP, die Identifikation der gebundenen Proteine und die Aufklärung des molekularen Mechanismus der Virulenzinhibition. Zwei Lactone zeigen eine starke Reduktion der Hämolyse und intrazellulären Replikation von Staphylococcus aureus durch Inhibi... »
- WWW:
- https://mediatum.ub.tum.de/?id=1178502
- Date of submission:
- 26.11.2013
- Oral examination:
- 23.01.2014
- File size:
- 33144870 bytes
- Pages:
- 182
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20140123-1178502-0-4
- Last change:
- 08.04.2015
BibTeX