The investigation of mechanisms in the extracellular stimulation of neural tissue is central in neuroprosthetics and brain research. In this work, the capacitive coupling of epithelial and brain tissue grown on oxidized silicon chips has been studied. In this context, a special focus was on the development of spatially and time resolved methods of analysis. With a combination of different high resolution methods, it was possible to achieve a detailed picture of the contact area and its local potential distribution. The findings allowed to develop an analytically soluble model which could easily be extended to more complex geometries.
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The investigation of mechanisms in the extracellular stimulation of neural tissue is central in neuroprosthetics and brain research. In this work, the capacitive coupling of epithelial and brain tissue grown on oxidized silicon chips has been studied. In this context, a special focus was on the development of spatially and time resolved methods of analysis. With a combination of different high resolution methods, it was possible to achieve a detailed picture of the contact area and its local pot...
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