The present study examined the effects of an isolated sepsis with E. coli bacteria on neuromuscular transmission and the expression of acetylcholin receptors in rats. Serum level of a1-acid glycoprotein increased over the time course of sepsis. Body weight gain, muscle weight and force generating capacity decreased compared to time matched controls.There was no significant difference in acetylcholine receptor expression. General catabolism is, therefore, a major factor for the muscle dysfunction seen during sepsis.
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The present study examined the effects of an isolated sepsis with E. coli bacteria on neuromuscular transmission and the expression of acetylcholin receptors in rats. Serum level of a1-acid glycoprotein increased over the time course of sepsis. Body weight gain, muscle weight and force generating capacity decreased compared to time matched controls.There was no significant difference in acetylcholine receptor expression. General catabolism is, therefore, a major factor for the muscle dysfunction...
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