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Document type:
journal article 
Author(s):
Zheng, F; Adelsberger, H; Müller, MR; Fritschy, JM; Werner, S; Alzheimer, C 
Title:
Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior. 
Abstract:
Activin, a member of the transforming growth factor-beta superfamily, affords neuroprotection in acute brain injury, but its physiological functions in normal adult brain are largely unknown. Using transgenic (tg) mice expressing a dominant-negative activin receptor mutant under the control of the CaMKIIalpha promoter in forebrain neurons, we identified activin as a key regulator of gamma-aminobutyric acid (GABA)ergic synapses and anxiety-like behavior. In the open field, wild-type (wt) and tg m...    »
 
Journal title abbreviation:
Mol Psychiatry 
Year:
2009 
Journal volume:
14 
Journal issue:
Pages contribution:
332-46 
Language:
eng 
Print-ISSN:
1359-4184 
TUM Institution:
Institut für Neurowissenschaften