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Document type:
journal article 
Author(s):
Rognoni, E; Widmaier, M; Haczek, C; Mantwill, K; Holzmüller, R; Gansbacher, B; Kolk, A; Schuster, T; Schmid, RM; Saur, D; Kaszubiak, A; Lage, H; Holm, PS 
Title:
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo. 
Abstract:
We have earlier described the oncolytic adenovirus vector dl520 that was rendered cancer-specific by deletion of the transactivation domain CR3 of the adenoviral E1A13S protein; this deletion causes antitumor activity in drug-resistant cells displaying nuclear YB-1 expression. We hypothesized that the anticancer activity of dl520 could be further improved by introducing the RGD motif in the fiber knob and by deletion of the adenoviral E1B19K protein (Ad-Delo3-RGD). In this study, the in vitro a...    »
 
Journal title abbreviation:
Cancer Gene Ther 
Year:
2009 
Journal volume:
16 
Journal issue:
10 
Pages contribution:
753-63 
Language:
eng 
Print-ISSN:
0929-1903 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie ; Institut für Medizinische Statistik und Epidemiologie ; II. Medizinische Klinik und Poliklinik